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Humira and fistula healing posted by guener guener , jul 9, 2016 i have a perianal fistula draining from my colon, and it has been easier to deal with since i. Ive been on humira for a couple months now, and im hoping that it will (help) heal my anal fistula. I didnt have the fistula, but the humira was pretty helpful. Anal fistula is a chronic abnormal communication between the epithelialised surface of the anal canal and usually the perianal skin. An anal fistula can be described as a narrow tunnel with its internal opening in the anal canal and its external opening in the skin near the anus. Anal fistulae commonly occur in people with a history of anal abscesses. Some data from a post i made a while back on the effectiveness of humira and remicade on fistula jonny five said. Remicade was studied in 1999 and shown to help heal fistula in somewhere around 60 of patients - with complete fistula closure after 6 weeks in 40-50 of patients. Anal fistula what is an anal fistula? An anal fistula is a small tunnel that connects an abscess, an infected cavity in the anus, to an opening on the skin around the anus. The anus is the external opening through which feces are expelled from the body. an anal fistula is a tunnel that runs from inside the anus-- the hole your body uses to get rid of solid waste -- to somewhere in the skin around it. I was on remicade with my previous doctor and when i got to vanderbilt, they started me on humira. This medicine seems to be doing better with me, but i have now had my second fistula and abcess show up. With this one, i hurt in my legs all the time, i got to where i hurt so bad just trying to bend over and i was getting to where i could not sit down comfortably. I had a seton placed due to a perianal fistula, but its still draining.